| First Author | Lader E | Year | 1989 |
| Journal | Cell | Volume | 58 |
| Issue | 5 | Pages | 969-79 |
| PubMed ID | 2570638 | Mgi Jnum | J:9988 |
| Mgi Id | MGI:58445 | Doi | 10.1016/0092-8674(89)90948-3 |
| Citation | Lader E, et al. (1989) tctex-1: a candidate gene family for a mouse t complex sterility locus. Cell 58(5):969-79 |
| abstractText | The t complex of the mouse has an important role in male germ cell development and function. Multiple mutations in the t complex interact to alter profoundly the transmission ratio of t complex-bearing sperm or to cause complete sterility or semisterility. We have isolated a multigene family, tctex-1, by screening a testicular cell cDNA library with two reciprocally subtracted testicular cDNA probes. The tctex-1 gene family produces an abundant, virtually germ cell-specific transcript that is 8-fold overexpressed in t homozygotes. The aberrant expression of tctex-1 is solely dependent on the t haplotype genes and occurs only in germ cells. The chromosomal location and pattern of expression of tctex-1 make it a candidate for involvement in male sterility. |
