| First Author | Rohan PJ | Year | 1993 |
| Journal | Science | Volume | 259 |
| Issue | 5102 | Pages | 1763-6 |
| PubMed ID | 7681221 | Mgi Jnum | J:22010 |
| Mgi Id | MGI:69904 | Doi | 10.1126/science.7681221 |
| Citation | Rohan PJ, et al. (1993) PAC-1: a mitogen-induced nuclear protein tyrosine phosphatase. Science 259(5102):1763-6 |
| abstractText | Tyrosine phosphorylation of proteins is required for signal transduction in cells and for growth regulation. A mitogen-induced gene (PAC-1) has been cloned from human T cells and encodes a 32-kilodalton protein that contains a sequence that defines the enzymatic site of known protein phosphotyrosine phosphatases (PTPases). Other than this sequence, PAC-1 is different from several other known related PTPases exemplified by PTP-1b. PAC-1 is similar to a phosphatase induced by mitogens or heat shock in fibroblasts, a yeast gene, and a vaccinia virus-encoded serine-tyrosine phosphatase (VH1). PAC-1 was predominantly expressed in hematopoietic tissues and localized to the nucleus in transfected COS-7 cells and in mitogen-stimulated T cells. |
