| First Author | de Lapeyriere O | Year | 1990 |
| Journal | Oncogene | Volume | 5 |
| Issue | 6 | Pages | 823-31 |
| PubMed ID | 2193291 | Mgi Jnum | J:10578 |
| Mgi Id | MGI:59026 | Citation | de Lapeyriere O, et al. (1990) Structure, chromosome mapping and expression of the murine Fgf-6 gene. Oncogene 5(6):823-31 |
| abstractText | The sixth member of the fibroblast growth factor gene family was cloned and analysed in the mouse. It is composed of three coding exons and encodes a putative growth protein of 198 amino acids, possessing a potential signal peptide, and presenting 79% and 93.5% sequence similarity with the mouse Hst/K-fgf and human FGF-6 genes products, respectively. The murine Fgf-6 gene is located in a region distinct from the Int-41 locus and belongs to a linkage group conserved between chromosome 12 in man and chromosome 6 in mouse. It presents an intrinsic oncogenic capacity since it is able to transform cultured fibroblasts. Fgf-6 mRNA levels are developmentally regulated with a peak of expression in the developing fetus at day 15.5 of gestation, moderate levels during late gestation and in the neonate. In the adult, Fgf-6 mRNA can be detected in testis, heart and skeletal muscle. |
