| First Author | Onodera T | Year | 2010 |
| Journal | Science | Volume | 329 |
| Issue | 5991 | Pages | 562-5 |
| PubMed ID | 20671187 | Mgi Jnum | J:162851 |
| Mgi Id | MGI:4820442 | Doi | 10.1126/science.1191880 |
| Citation | Onodera T, et al. (2010) Btbd7 regulates epithelial cell dynamics and branching morphogenesis. Science 329(5991):562-5 |
| abstractText | During embryonic development, many organs form by extensive branching of epithelia through the formation of clefts and buds. In cleft formation, buds are delineated by the conversion of epithelial cell-cell adhesions to cell-matrix adhesions, but the mechanisms of cleft formation are not clear. We have identified Btbd7 as a dynamic regulator of branching morphogenesis. Btbd7 provides a mechanistic link between the extracellular matrix and cleft propagation through its highly focal expression leading to local regulation of Snail2 (Slug), E-cadherin, and epithelial cell motility. Inhibition experiments show that Btbd7 is required for branching of embryonic mammalian salivary glands and lungs. Hence, Btbd7 is a regulatory gene that promotes epithelial tissue remodeling and formation of branched organs. |
