| First Author | Haupt Y | Year | 1991 |
| Journal | Cell | Volume | 65 |
| Issue | 5 | Pages | 753-63 |
| PubMed ID | 1904009 | Mgi Jnum | J:11214 |
| Mgi Id | MGI:59655 | Doi | 10.1016/0092-8674(91)90383-a |
| Citation | Haupt Y, et al. (1991) Novel zinc finger gene implicated as myc collaborator by retrovirally accelerated lymphomagenesis in E mu-myc transgenic mice [see comments]. Cell 65(5):753-63 |
| abstractText | To search for genes that can collaborate with myc in lymphomagenesis, we exploited retroviral insertional mutagenesis in E mu-myc transgenic mice. Moloney murine leukemia virus accelerated development of B lymphoid tumors. Three quarters contained a provirus within the known pim-1 or pim-2 loci, new loci bmi-1 and emi-1, or combinations of these. bmi-1 insertions predominated, occurring in half the tumors, and resulted in elevated bmi-1 mRNA levels. Significantly, the bmi-1 gene, which is expressed in diverse normal cells, encodes a Cys/His metal-binding motif (C3HC4) that resembles those in several DNA-binding proteins and defines a new category of zinc finger gene. Thus, myc-induced lymphomagenesis can entail the concerted action of several genes, including the presumptive nuclear regulator bmi-1. |
