| First Author | Liu YJ | Year | 2012 |
| Journal | Biol Reprod | Volume | 86 |
| Issue | 2 | Pages | 40 |
| PubMed ID | 22034526 | Mgi Jnum | J:185777 |
| Mgi Id | MGI:5429840 | Doi | 10.1095/biolreprod.111.095018 |
| Citation | Liu YJ, et al. (2012) Essential role of DPPA3 for chromatin condensation in mouse oocytogenesis. Biol Reprod 86(2):40 |
| abstractText | Dynamic alterations in chromatin configuration occur in mammalian oocytogenesis. Based on chromatin configuration patterns, fully grown oocytes are classified into two types. One is surrounded nucleolus (SN)-type and the other is nonsurrounded nucleolus (NSN)-type oocytes. Although chromatin condensation during the transition from NSN- to SN-type oocytes is a prerequisite for normal early embryonic development, the molecular mechanisms remain unclear. In this study, we analyzed the role of DPPA3 (also known as PGC7/Stella) in this transition using Dppa3-null oocytes. The NSN-to-SN transition was significantly impaired, and transcriptional repression was incomplete in the Dppa3-null oocytes. Additionally, we revealed that prior transcriptional repression was necessary for the NSN-to-SN transition. These findings demonstrate that DPPA3 is an essential factor for the production of functional oocytes through transcriptional repression and chromatin condensation. |
