| First Author | Zhang Y | Year | 2004 |
| Journal | Mol Endocrinol | Volume | 18 |
| Issue | 4 | Pages | 851-62 |
| PubMed ID | 14715930 | Mgi Jnum | J:87192 |
| Mgi Id | MGI:2683856 | Doi | 10.1210/me.2003-0285 |
| Citation | Zhang Y, et al. (2004) Identification of a liver-specific uridine phosphorylase that is regulated by multiple lipid-sensing nuclear receptors. Mol Endocrinol 18(4):851-62 |
| abstractText | In this work, we report the characterization of a novel liver-specific gene (L-UrdPase), whose expression is regulated by a number of hepatic nuclear receptors (including liver X receptors, peroxisome proliferator-activated receptor alpha, farnesoid X receptor, and hepatic nuclear factor-4alpha), which have been shown to be involved in lipid metabolism. L-UrdPase encodes a previously uncharacterized protein with similarity to an intestine-specific uridine phosphorylase. Enzymatic assays confirmed that L-UrdPase has uridine phosphorylase activity. However, L-UrdPase has a highly restricted, nonoverlapping pattern of expression with its intestinal counterpart and is regulated in a distinct manner by several different nuclear receptors. The identification of the liver uridine phosphorylase and its characterization as a target of lipid-sensing nuclear receptors implies the existence of a previously unknown nuclear receptor signaling pathway that links lipid and uridine metabolism. |
