| First Author | Sainz E | Year | 2001 |
| Journal | J Neurochem | Volume | 77 |
| Issue | 3 | Pages | 896-903 |
| PubMed ID | 11331418 | Mgi Jnum | J:69265 |
| Mgi Id | MGI:1934393 | Doi | 10.1046/j.1471-4159.2001.00292.x |
| Citation | Sainz E, et al. (2001) Identification of a novel member of the T1R family of putative taste receptors. J Neurochem 77(3):896-903 |
| abstractText | In the gustatory system, the recognition of sugars, amino acids and bitter-tasting compounds is the function of specialized G protein-coupled receptors. Recently, two members of novel subfamily of G protein-coupled receptors were proposed to function as taste receptors based on their specific expression in taste receptor cells. Here, we report the identification of a third member, T1R3, of this family of receptors. T1R3 maps near the telomere of mouse chromosome 4 rendering it a candidate for the Sac locus, a primary determinant of sweet preference in mice. Consistent with its candidacy for the Sac locus, T1R3 displays taste receptor cell-specific expression. In addition, taster and non-taster strains of mouse harbor different alleles of T1R3. |
