| First Author | Chinery R | Year | 1996 |
| Journal | Gene | Volume | 171 |
| Issue | 2 | Pages | 249-53 |
| PubMed ID | 8666281 | Mgi Jnum | J:33631 |
| Mgi Id | MGI:81109 | Doi | 10.1016/0378-1119(96)00074-1 |
| Citation | Chinery R, et al. (1996) The gene encoding mouse intestinal trefoil factor: structural organization, partial sequence analysis and mapping to murine chromosome 17q. Gene 171(2):249-53 |
| abstractText | Trefoil peptides, a growing family of secretory molecules, have been identified mainly in the gastrointestinal tract of humans, rodents and amphibians. In the present study, the nucleotide sequence of a large portion (81%) of the gene encoding murine intestinal trefoil factor (mITF) and its whole genomic organization were determined. The mITF gene contains three exons distributed over 5 kb of genomic DNA. The genomic sequence is highly conserved, as compared with that of the rat and human ITF, and contains several AP-1-binding sites, the consensus binding site for the transcription factor Sp1, and a sequence homologous to a heat-shock element. Fluorescence in situ hybridization was used to assign ITF to chromosome 17 of the murine genome, a region syntenic with the trefoil gene cluster on human chromosome 21q22.3. |
