First Author | Hamada T | Year | 1996 |
Journal | Gene | Volume | 176 |
Issue | 1-2 | Pages | 211-4 |
PubMed ID | 8918255 | Mgi Jnum | J:36466 |
Mgi Id | MGI:83893 | Doi | 10.1016/0378-1119(96)00251-x |
Citation | Hamada T, et al. (1996) Isolation and characterization of a novel secretory protein, stromal cell-derived factor-2 (SDF-2) using the signal sequence trap method. Gene 176(1-2):211-4 |
abstractText | With use of the signal sequence trap method, we isolated a cDNA encoding a novel secretory protein, SDF-2, from the mouse stromal cell line, ST2. The human homologue of SDF-2 was also isolated. The amino acid (aa) sequences deduced from both the clones were conserved more than 92%. The chromosomal localization of the human SDF-2 gene was mapped to 17q11.2. The aa sequence of SDF-2 shows similarity to those of yeast dolichyl phosphate-D- mannose:protein mannosyltransferases, Pmt1p [Strahl- Bolsinger et al. (1993) Proc. Natl. Acad. Sci. USA 90, 8164-8168] and Pmt2p [Lussier et al. (1995) J. Biol. Chem. 270, 2770-2775], whose activities have not been detected in higher eukaryotes. |