| First Author | Gupta V | Year | 2006 |
| Journal | Biochem Biophys Res Commun | Volume | 345 |
| Issue | 1 | Pages | 74-7 |
| PubMed ID | 16678795 | Mgi Jnum | J:108971 |
| Mgi Id | MGI:3625543 | Doi | 10.1016/j.bbrc.2006.03.232 |
| Citation | Gupta V, et al. (2006) Modification of Msx1 by SUMO-1. Biochem Biophys Res Commun 345(1):74-7 |
| abstractText | The small ubiquitin-related modifier SUMO reversibly modifies many proteins, including promoter-specific transcription factors. Genetic studies in both humans and mice indicate that the Msx1 transcription factor is associated with specific disorders, including cleft palate. We show that Msx1 conjugation to SUMO-1 in vivo is enhanced by an E3 SUMO ligase, PIAS1, suggesting that sumoylation of Msx1 is a new mechanism for modulating the molecular function of Msx1 during organogenesis. |
