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Publication : Synthesis and SAR of potent LXR agonists containing an indole pharmacophore.

First Author  Washburn DG Year  2009
Journal  Bioorg Med Chem Lett Volume  19
Issue  4 Pages  1097-100
PubMed ID  19167885 Mgi Jnum  J:320338
Mgi Id  MGI:6872266 Doi  10.1016/j.bmcl.2009.01.004
Citation  Washburn DG, et al. (2009) Synthesis and SAR of potent LXR agonists containing an indole pharmacophore. Bioorg Med Chem Lett 19(4):1097-100
abstractText  A novel series of 1H-indol-1-yl tertiary amine LXR agonists has been designed. Compounds from this series were potent agonists with good rat pharmacokinetic parameters. In addition, the crystal structure of an LXR agonist bound to LXRalpha will be disclosed.
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