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Publication : Comparative expression of mouse and chicken Shisa homologues during early development.

First Author  Filipe M Year  2006
Journal  Dev Dyn Volume  235
Issue  9 Pages  2567-73
PubMed ID  16773659 Mgi Jnum  J:111615
Mgi Id  MGI:3654581 Doi  10.1002/dvdy.20862
Citation  Filipe M, et al. (2006) Comparative expression of mouse and chicken shisa homologues during early development. Dev Dyn 235(9):2567-2573
abstractText  During vertebrate embryogenesis, fibroblast growth factor (FGF) and Wnt signaling have been implicated in diverse cellular processes, including cell growth, differentiation, and tissue patterning. The recently identified Xenopus Shisa protein promotes head formation by inhibiting Wnt and FGF signaling through its interaction with the immature forms of Frizzled and FGF receptors in the endoplasmic reticulum, which prevents their posttranslational maturation. Here, we describe the mouse and chicken homologues of Xenopus Shisa. The mouse and chicken Shisa proteins share, respectively, 33.6% and 33.8% identity with the Xenopus homolog. In situ hybridization analysis shows that mouse shisa is expressed throughout embryonic development, predominantly in the anterior visceral endoderm, headfolds, somites, forebrain, optic vesicle, and limb buds. Cross-species comparison shows that the expression pattern of cshisa closely mirrors that of mshisa. Our observations indicate that the Shisa family genes are typically expressed in tissues known to require the modulation of Wnt and FGF signaling. Developmental Dynamics 235:2567-2573, 2006. (c) 2006 Wiley-Liss, Inc.
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