| First Author | Chan JY | Year | 1998 |
| Journal | EMBO J | Volume | 17 |
| Issue | 6 | Pages | 1779-87 |
| PubMed ID | 9501099 | Mgi Jnum | J:46990 |
| Mgi Id | MGI:1202470 | Doi | 10.1093/emboj/17.6.1779 |
| Citation | Chan JY, et al. (1998) Targeted disruption of the ubiquitous CNC-bZIP transcription factor, Nrf-1, results in anemia and embryonic lethality in mice. EMBO J 17(6):1779-87 |
| abstractText | The CNC-basic leucine zipper (CNC-bZIP) family is a subfamily of bZIP proteins identified from independent searches for factors that bind the AP-1-like cis-elements in the beta-globin locus control region. Three members, p45-Nf-e2, Nrf-1 and Nrf-2 have been identified in mammals. Expression of p45-Nf-e2 is largely restricted to hematopoietic cells while Nrf-1 and Nrf-2 are expressed in a wide range of tissues. To determine the function of Nrf-1, targeted disruption of the Nrf-1 gene was carried out. Homozygous Nrf-1 mutant mice are anemic due to a non-cell autonomous defect in definitive erythropoiesis and die in utero. |
