| First Author | Zinn AR | Year | 1991 |
| Journal | Genomics | Volume | 11 |
| Issue | 4 | Pages | 1097-101 |
| PubMed ID | 1783379 | Mgi Jnum | J:4626 |
| Mgi Id | MGI:53111 | Doi | 10.1016/0888-7543(91)90037-f |
| Citation | Zinn AR, et al. (1991) Inactivation of the Rps4 gene on the mouse X chromosome [published erratum appears in Genomics 1992 Jul;13(3):915]. Genomics 11(4):1097-101 |
| abstractText | The human RPS4X and RPS4Y genes, located on the X and Y chromosomes, appear to encode isoforms of ribosomal protein S4. Haploinsufficiency of these genes may contribute to the human phenotype known as Turner syndrome. Although RPS4X maps near the X-inactivation center, the gene is expressed on inactive human X chromosomes. We cloned Rps4, the mouse homolog of RPS4X. Exploiting allelic variation in Rps4, we examined transcription of the gene from active and inactive mouse X chromosomes in vivo, in female mice carrying an X-autosome translocation. We report that mouse Rps4, unlike human RPS4X, is subject to X inactivation. This finding may explain, at least in part, why the phenotypic consequences of X monosomy are less severe in mice than in humans. |
