| First Author | Patwardhan S | Year | 1991 |
| Journal | Oncogene | Volume | 6 |
| Issue | 6 | Pages | 917-28 |
| PubMed ID | 1906159 | Mgi Jnum | J:49519 |
| Mgi Id | MGI:1289106 | Citation | Patwardhan S, et al. (1991) EGR3, a novel member of the Egr family of genes encoding immediate-early transcription factors. Oncogene 6(6):917-28 |
| abstractText | We have previously described two cellular immediate-early genes, Egr-1 (mouse) and EGR2 (human) that encode zinc finger proteins. Here we report the characterization of a new member of the Egr family referred to as EGR3 (human). This cDNA clone was isolated using low stringency hybridization with the zinc finger domain of Egr-1. The EGR3 cDNA sequence predicts a 387 amino acid (a.a.) protein containing three Cys2-His2 zinc fingers nearly identical to those of Egr-1 and EGR2. This similarity has a functional consequence: EGR3 can activate transcription of a CAT gene linked to the sequence CGCCCCCGC, a cis element which is a target for Egr-1 and EGR2. We show that EGR3 is an immediate-early growth response gene induced by mitogenic stimulation of rodent and human fibroblasts and a monkey kidney epithelial cell line. The EGR3 gene has a single intron and maps to chromosome 8 at bands p21-23. |
