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Publication : The amyloid beta protein precursor or proteinase nexin II from mouse is closer related to its human homolog than previously reported.

First Author  De Strooper B Year  1991
Journal  Biochim Biophys Acta Volume  1129
Issue  1 Pages  141-3
PubMed ID  1756177 Mgi Jnum  J:2308
Mgi Id  MGI:50832 Doi  10.1016/0167-4781(91)90231-a
Citation  De Strooper B, et al. (1991) The amyloid beta protein precursor or proteinase nexin II from mouse is closer related to its human homolog than previously reported. Biochim Biophys Acta 1129(1):141-3
abstractText  The cDNA sequence for amyloid precursor protein and the two alternatively spliced forms were determined. Seven nucleotide differences resulting in six amino acid differences compared to the previously published mouse sequence were found. Moreover, the 3' non-coding end was completely different. Part of these findings were confirmed in three different mouse strains. The resulting mouse cDNA resembles the human APP more closely than originally reported.
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