| First Author | King DP | Year | 1997 |
| Journal | Cell | Volume | 89 |
| Issue | 4 | Pages | 641-53 |
| PubMed ID | 9160755 | Mgi Jnum | J:40364 |
| Mgi Id | MGI:87704 | Doi | 10.1016/s0092-8674(00)80245-7 |
| Citation | King DP, et al. (1997) Positional cloning of the mouse circadian clock gene. Cell 89(4):641-53 |
| abstractText | We used positional cloning to identify the circadian Clock gene in mice. Clock is a large transcription unit with 24 exons spanning similar to 100,000 bp of DNA from which transcript classes of 7.5 and similar to 10 kb arise. Clock encodes a novel member of the bHLH-PAS family of transcription factors. In the Clock mutant allele, an A-- >T nucleotide transversion in a splice donor site causes exon skipping and deletion of 51 amino acids in the CLOCK protein. Clock is a unique gene with known circadian function and with features predicting DNA binding, protein dimerization, and activation domains. CLOCK represents the second example of a PAS domain-containing clock protein (besides Drosophila PERIOD), which suggests that this motif may define an evolutionarily conserved feature of the circadian clock mechanism. |
