| First Author | Colonna M | Year | 2000 |
| Journal | Eur J Immunol | Volume | 30 |
| Issue | 2 | Pages | 697-704 |
| PubMed ID | 10671229 | Mgi Jnum | J:64945 |
| Mgi Id | MGI:1891492 | Doi | 10.1002/1521-4141(200002)30:2<697::AID-IMMU697>3.0.CO;2-M |
| Citation | Colonna M, et al. (2000) Molecular characterization of two novel C-type lectin-like receptors, one of which is selectively expressed in human dendritic cells. Eur J Immunol 30(2):697-704 |
| abstractText | We have identified two human C-type lectin-like receptors, CLEC-1 and CLEC-2. Both display a single carbohydrate recognition domain and a cytoplasmic tyrosine-based motif. They are homologous to the NK cell receptors NKG2s and CD94 and also to the oxidized low-density lipoprotein receptor 1. CLEC-1 and CLEC-2 are preferentially transcribed in dendritic cells (DC) and in the liver, respectively. Following transient transfection in COS cells, CLEC-1 is expressed intracellularly, perhaps requiring an associated chain to reach the cell surface. CLEC-2 is expressed on the surface of transfected cells as a protein of approximately 33 kDa. CLEC-1 and CLEC-2 genes map to human chromosome 12, most likely in linkage with the NK gene complex (NKC). Thus, the NKC may encode C-type lectin-like receptors expressed not only in NK cells but also in other cells, and at least one of these is of potential importance in regulating DC function. |
