| First Author | Tago K | Year | 2000 |
| Journal | Genes Dev | Volume | 14 |
| Issue | 14 | Pages | 1741-9 |
| PubMed ID | 10898789 | Mgi Jnum | J:74520 |
| Mgi Id | MGI:2158579 | Doi | 10.1101/gad.14.14.1741 |
| Citation | Tago K, et al. (2000) Inhibition of Wnt signaling by ICAT, a novel beta-catenin-interacting protein. Genes Dev 14(14):1741-9 |
| abstractText | Wnt signaling has an important role in both embryonic development and tumorigenesis. beta-Catenin, a key component of the Wnt signaling pathway, interacts with the TCF/LEF family of transcription factors and activates transcription of Wnt target genes. Here, we identify a novel beta-catenin-interacting protein, ICAT, that was found to inhibit the interaction of beta-catenin with TCF-4 and represses beta-catenin-TCF-4-mediated transactivation. Furthermore, ICAT inhibited Xenopus axis formation by interfering with Wnt signaling. These results suggest that ICAT negatively regulates Wnt signaling via inhibition of the interaction between beta-catenin and TCF and is integral in development and cell proliferation. |
