| First Author | Achen MG | Year | 1997 |
| Journal | Growth Factors | Volume | 15 |
| Issue | 1 | Pages | 69-80 |
| PubMed ID | 9401819 | Mgi Jnum | J:44540 |
| Mgi Id | MGI:1100424 | Doi | 10.3109/08977199709002113 |
| Citation | Achen MG, et al. (1997) Placenta growth factor and vascular endothelial growth factor are co-expressed during early embryonic development. Growth Factors 15(1):69-80 |
| abstractText | We have used the polymerase chain reaction to identify mouse proteins similar in primary structure to the endothelial cell mitogen Vascular Endothelial Growth Factor (VEGF). One amplified product encoded mouse Placenta Growth Factor (PIGF). The pattern of PIGF gene expression in mouse embryos was studied by in situ hybridization. Transcripts encoding mouse PIGF were abundant in trophoblastic giant cells associated with the parietal yolk sac at early stages of embryogenesis. VEGF transcripts were also detected in trophoblastic giant cells raising the possibility that these cells may secrete heterodimers consisting of one PIGF subunit and one VEGF subunit. The secretion of PIGF and VEGF by trophoblastic giant cells is likely to be the signal which initiates and co-ordinates vascularization in the deciduum and placenta during early embryogenesis. |
