| First Author | Siggs OM | Year | 2012 |
| Journal | J Exp Med | Volume | 209 |
| Issue | 1 | Pages | 19-27 |
| PubMed ID | 22201126 | Mgi Jnum | J:178820 |
| Mgi Id | MGI:5300225 | Doi | 10.1084/jem.20112084 |
| Citation | Siggs OM, et al. (2012) ZBTB1 is a determinant of lymphoid development. J Exp Med 209(1):19-27 |
| abstractText | In this study, we describe a chemically induced mouse mutation that caused a complete and cell-intrinsic T cell deficiency. Development of other lymphoid lineages was also partially impaired and was severely compromised under competitive conditions. Positional cloning, retroviral transduction, and a somatic reversion event revealed that the causative mutation lay within Zbtb1 (zinc finger and BTB domain containing 1), a gene conserved throughout vertebrate evolution. Our data establish ZBTB1 as a critical determinant of T cell development and lymphopoiesis in general, most likely by acting as a transcriptional regulator. |
