| First Author | Maeda T | Year | 2007 |
| Journal | Science | Volume | 316 |
| Issue | 5826 | Pages | 860-6 |
| PubMed ID | 17495164 | Mgi Jnum | J:121576 |
| Mgi Id | MGI:3710692 | Doi | 10.1126/science.1140881 |
| Citation | Maeda T, et al. (2007) Regulation of B versus T lymphoid lineage fate decision by the proto-oncogene LRF. Science 316(5826):860-6 |
| abstractText | Hematopoietic stem cells in the bone marrow give rise to lymphoid progenitors, which subsequently differentiate into B and T lymphocytes. Here we show that the proto-oncogene LRF plays an essential role in the B versus T lymphoid cell-fate decision. We demonstrate that LRF is key for instructing early lymphoid progenitors in mice to develop into B lineage cells by repressing T cell-instructive signals produced by the cell-fate signal protein, Notch. We propose a new model for lymphoid lineage commitment, in which LRF acts as a master regulator of the cell's determination of B versus T lineage. |
