| First Author | Kanzaki M | Year | 1999 |
| Journal | Nat Cell Biol | Volume | 1 |
| Issue | 3 | Pages | 165-70 |
| PubMed ID | 10559903 | Mgi Jnum | J:53008 |
| Mgi Id | MGI:1341057 | Doi | 10.1038/11086 |
| Citation | Kanzaki M, et al. (1999) Translocation of a calcium-permeable cation channel induced by insulin-like growth factor-1. Nat Cell Biol 1:165-170 |
| abstractText | Calcium plays a critical part in the regulation of cell growth, and growth factors stimulate calcium entry into cells through calcium-permeable channels. However, the molecular nature and regulation of calcium-permeable channels are still unclear at present. Here we report the molecular characterization of a calcium-permeable cation channel that is regulated by insulin-like growth factor-I (IGF-I). This channel, which we name growth-factor-regulated channel (GRC), belongs to the TRP-channel family and localizes mainly to intracellular pools under basal conditions. Upon stimulation of cells by IGF-I, GRC translocates to the plasma membrane. Thus, IGF-I augments calcium entry through GRC by regulating trafficking of the channel. |
