| First Author | Clark K | Year | 2002 |
| Journal | FEBS Lett | Volume | 523 |
| Issue | 1-3 | Pages | 12-6 |
| PubMed ID | 12123796 | Mgi Jnum | J:78151 |
| Mgi Id | MGI:2183626 | Doi | 10.1016/s0014-5793(02)02904-6 |
| Citation | Clark K, et al. (2002) Temporal and spatial expression of two isoforms of the Dutt1/Robo1 gene in mouse development. FEBS Lett 523(1-3):12-6 |
| abstractText | The mammalian homologue of the Drosophila axonal guidance receptor roundabout is expressed in a wide range of tissues. Here we show that alternative splicing of the Dutt1/Robo1 gene results in two mRNA transcripts with different signal peptides, which are differentially expressed throughout mouse embryogenesis. Since mice with a targeted deletion in the Dutt1/Robo1 gene have abnormal lung pathology, immunohistochemistry was used to identify the cellular expression pattern of Dutt1/Robo1 during lung development. Dutt1/Robo1 expression was widespread and diffuse in the lung at embryonic day 17.5 but became increasingly localised to the bronchial epithelium in newborn and adult mice. |
