| First Author | Diebold SS | Year | 2004 |
| Journal | Science | Volume | 303 |
| Issue | 5663 | Pages | 1529-31 |
| PubMed ID | 14976261 | Mgi Jnum | J:90024 |
| Mgi Id | MGI:3042320 | Doi | 10.1126/science.1093616 |
| Citation | Diebold SS, et al. (2004) Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science 303(5663):1529-31 |
| abstractText | Interferons (IFNs) are critical for protection from viral infection, but the pathways linking virus recognition to IFN induction remain poorly understood. Plasmacytoid dendritic cells produce vast amounts of IFN-alpha in response to the wild-type influenza virus. Here, we show that this requires endosomal recognition of influenza genomic RNA and signaling by means of Toll-like receptor 7 (TLR7) and MyD88. Single-stranded RNA (ssRNA) molecules of nonviral origin also induce TLR7-dependent production of inflammatory cytokines. These results identify ssRNA as a ligand for TLR7 and suggest that cells of the innate immune system sense endosomal ssRNA to detect infection by RNA viruses. |
