| First Author | von Eyss B | Year | 2015 |
| Journal | Cancer Cell | Volume | 28 |
| Issue | 6 | Pages | 743-757 |
| PubMed ID | 26678338 | Mgi Jnum | J:227409 |
| Mgi Id | MGI:5700437 | Doi | 10.1016/j.ccell.2015.10.013 |
| Citation | von Eyss B, et al. (2015) A MYC-Driven Change in Mitochondrial Dynamics Limits YAP/TAZ Function in Mammary Epithelial Cells and Breast Cancer. Cancer Cell 28(6):743-57 |
| abstractText | In several developmental lineages, an increase in MYC expression drives the transition from quiescent stem cells to transit-amplifying cells. We show that MYC activates a stereotypic transcriptional program of genes involved in cell growth in mammary epithelial cells. This change in gene expression indirectly inhibits the YAP/TAZ co-activators, which maintain the clonogenic potential of these cells. We identify a phospholipase of the mitochondrial outer membrane, PLD6, as the mediator of MYC activity. MYC-dependent growth strains cellular energy resources and stimulates AMP-activated kinase (AMPK). PLD6 alters mitochondrial fusion and fission dynamics downstream of MYC. This change activates AMPK, which in turn inhibits YAP/TAZ. Mouse models and human pathological data show that MYC enhances AMPK and suppresses YAP/TAZ activity in mammary tumors. |
