| First Author | Iwama A | Year | 1993 |
| Journal | Biochem Biophys Res Commun | Volume | 195 |
| Issue | 1 | Pages | 301-9 |
| PubMed ID | 8395828 | Mgi Jnum | J:14345 |
| Mgi Id | MGI:62516 | Doi | 10.1006/bbrc.1993.2045 |
| Citation | Iwama A, et al. (1993) Molecular cloning and characterization of mouse TIE and TEK receptor tyrosine kinase genes and their expression in hematopoietic stem cells. Biochem Biophys Res Commun 195(1):301-9 |
| abstractText | To identify receptor tyrosine kinases (RTKs) critical to early hematopoiesis, we performed polymerase chain reaction-based cloning from yolk sac and highly enriched bone marrow hematopoietic stem cells (HSCs). Characterization of two novel genes of their full-length cDNA sequences revealed that they were mouse homologues of the endothelial cell RTK genes, TIE and TEK. They shared a unique structural property of coexistent immunoglobulin-like domain, epidermal growth factor-like repeats, and fibronectin type III repeats in their extracellular domains. Both genes were expressed in a similar fashion in adult tissues and primitive hematopoietic cells, predominantly in the bone marrow HSCs. |
