| First Author | Inada H | Year | 2008 |
| Journal | EMBO Rep | Volume | 9 |
| Issue | 7 | Pages | 690-7 |
| PubMed ID | 18535624 | Mgi Jnum | J:359371 |
| Mgi Id | MGI:7787305 | Doi | 10.1038/embor.2008.89 |
| Citation | Inada H, et al. (2008) Off-response property of an acid-activated cation channel complex PKD1L3-PKD2L1. EMBO Rep 9(7):690-7 |
| abstractText | Ligand-gated ion channels are important in sensory and synaptic transduction. The PKD1L3-PKD2L1 channel complex is a sour taste receptor candidate that is activated by acids. Here, we report that the proton-activated PKD1L3-PKD2L1 ion channels have the unique ability to be activated after the removal of an acid stimulus. We refer to this property as the off-response (previously described as a delayed response). Electrophysiological analyses show that acid-induced responses are observed only after the removal of an acid solution at less than pH 3.0. A small increase in pH is sufficient for PKD1L3-PKD2L1 channel activation, after exposure to an acid at pH 2.5. These results indicate that this channel is a new type of ion channel-designated as an 'off-channel'-which is activated during stimulus application but not gated open until the removal of the stimulus. The off-response property of PKD1L3-PKD2L1 channels might explain the physiological phenomena occurring during sour taste sensation. |
