| First Author | Lee KN | Year | 2005 |
| Journal | Immunity | Volume | 22 |
| Issue | 2 | Pages | 195-208 |
| PubMed ID | 15723808 | Mgi Jnum | J:96677 |
| Mgi Id | MGI:3531242 | Doi | 10.1016/j.immuni.2004.12.012 |
| Citation | Lee KN, et al. (2005) VDUP1 is required for the development of natural killer cells. Immunity 22(2):195-208 |
| abstractText | Vitamin D3 upregulated protein 1 (VDUP1) is a stress-response gene that is upregulated by 1,25(OH)2D3 in tumor cells. The in vivo roles of VDUP1 were investigated by producing mice lacking VDUP1 (VDUP1-/- mice). VDUP1-/- mice showed minimal changes in the development of T and B cells, but there was a profound reduction in the numbers of natural killer (NK) cells. As well, these mice showed decreased NK activity. In the VDUP1-/- mice, the expression of CD122 was reduced, demonstrating that VDUP1 is required for CD122 expression and NK maturation. In addition, severe lymphoid hyperplasia in the small intestine was observed in VDUP1-/- mice. Taken together, these results suggest that VDUP1 is a critical factor for the development and function of NK cells in vivo. |
