| First Author | Kaartinen V | Year | 1995 |
| Journal | Nat Genet | Volume | 11 |
| Issue | 4 | Pages | 415-21 |
| PubMed ID | 7493022 | Mgi Jnum | J:29902 |
| Mgi Id | MGI:77427 | Doi | 10.1038/ng1295-415 |
| Citation | Kaartinen V, et al. (1995) Abnormal lung development and cleft palate in mice lacking TGF-beta 3 indicates defects of epithelial-mesenchymal interaction. Nat Genet 11(4):415-21 |
| abstractText | A broad spectrum of biological activities has been proposed for transforming growth factor-beta 3 (TGF-beta 3). To study TGF-beta 3 function in development, TGF-beta 3 null mutant mice were generated by gene-targeting. Within 20 hours of birth, homozygous TGF-beta 3-/- mice die with unique and consistent phenotypic features including delayed pulmonary development and defective palatogenesis. Unlike other null mutants with cleft palate, TGF-beta 3-/- mice lack other concomitant craniofacial abnormalities. This study demonstrates an essential function for TGF-beta 3 in the normal morphogenesis of palate and lung, and directly implicates this cytokine in mechanisms of epithelial-mesenchymal interaction. |
