| First Author | Shimoda K | Year | 2000 |
| Journal | Immunity | Volume | 13 |
| Issue | 4 | Pages | 561-71 |
| PubMed ID | 11070174 | Mgi Jnum | J:65409 |
| Mgi Id | MGI:1926545 | Doi | 10.1016/s1074-7613(00)00055-8 |
| Citation | Shimoda K, et al. (2000) Tyk2 plays a restricted role in IFN alpha signaling, although it is required for IL-12-mediated T cell function. Immunity 13(4):561-71 |
| abstractText | Janus kinases (Jaks) play an important role in signal transduction via cytokine receptors. Tyk2 is a Janus kinase, and we developed tyk2-deficient mice to study the requirement for tyk2 in vivo. Tyk2-deficient mice show no overt developmental abnormalities; however, they display a lack of responsiveness to a small amount of IFNalpha, although a high concentration of IFNalpha can fully transduce its signal even in the absence of tyk2. Furthermore, IL-12-induced T cell function is defective in these mice. In contrast, these mice respond normally to IL-6 and IL-10, both of which activate tyk2 in vitro. These observations demonstrate that tyk2 plays only a restricted role in mediating IFNalpha-dependent signaling while being required in mediating IL-12-dependent biological responses. |
