| First Author | Caubit X | Year | 2010 |
| Journal | J Neurosci | Volume | 30 |
| Issue | 28 | Pages | 9465-76 |
| PubMed ID | 20631175 | Mgi Jnum | J:162557 |
| Mgi Id | MGI:4819308 | Doi | 10.1523/JNEUROSCI.1765-10.2010 |
| Citation | Caubit X, et al. (2010) Teashirt 3 regulates development of neurons involved in both respiratory rhythm and airflow control. J Neurosci 30(28):9465-76 |
| abstractText | Neonatal breathing in mammals involves multiple neuronal circuits, but its genetic basis remains unclear. Mice deficient for the zinc finger protein Teashirt 3 (TSHZ3) fail to breathe and die at birth. Tshz3 is expressed in multiple areas of the brainstem involved in respiration, including the pre-Botzinger complex (preBotC), the embryonic parafacial respiratory group (e-pF), and cranial motoneurons that control the upper airways. Tshz3 inactivation led to pronounced cell death of motoneurons in the nucleus ambiguus and induced strong alterations of rhythmogenesis in the e-pF oscillator. In contrast, the preBotC oscillator appeared to be unaffected. These deficits result in impaired upper airway function, abnormal central respiratory rhythm generation, and altered responses to pH changes. Thus, a single gene, Tshz3, controls the development of diverse components of the circuitry required for breathing. |
