| First Author | Schulz TC | Year | 1995 |
| Journal | Biochem J | Volume | 311 ( Pt 1) |
| Pages | 219-24 | PubMed ID | 7575457 |
| Mgi Jnum | J:29058 | Mgi Id | MGI:76582 |
| Doi | 10.1042/bj3110219 | Citation | Schulz TC, et al. (1995) An unusual arrangement of 13 zinc fingers in the vertebrate gene Z13. Biochem J 311(Pt 1):219-24 |
| abstractText | The zinc finger is a protein domain that imparts specific nucleic acid-binding activity on a wide range of functionally important proteins. In this paper we report the molecular cloning and characterization of a novel murine zinc-finger gene, mZ13. Analysis of mZ13 cDNAs revealed that the gene expresses a 794-amino-acid protein encoded by a 2.7 kb transcript. The protein has an unusual arrangement of 13 zinc fingers into a 'hand' of 12 tandem fingers and a single isolated finger near the C-terminus. This structural organization is conserved with the probable chicken homologue, cZ13. mZ13 also contained an additional domain at the N-terminus which has previously been implicated in the regulation of zinc-finger transcription factor DNA-binding, via protein-protein interactions. mZ13 expression was detected in a wide range of murine embryonic and adult tissues. The structural organization of mZ13 and its expression profile suggest that it may function as a housekeeping DNA-binding protein that regulates the expression of specific genes. |
