| First Author | Miaw SC | Year | 2000 |
| Journal | Immunity | Volume | 12 |
| Issue | 3 | Pages | 323-33 |
| PubMed ID | 10755619 | Mgi Jnum | J:64944 |
| Mgi Id | MGI:1891490 | Doi | 10.1016/s1074-7613(00)80185-5 |
| Citation | Miaw SC, et al. (2000) ROG, repressor of GATA, regulates the expression of cytokine genes. Immunity 12(3):323-33 |
| abstractText | GATA-3 is a T cell-specific transcription factor and is essential for the development of the T cell lineage. Recently, it was shown that the expression of GATA-3 is further induced in CD4+ helper T cells upon differentiation into type 2 but not type 1 effector cells. Here, we report the molecular cloning of a GATA-3 interacting protein, repressor of GATA (ROG). ROG is a lymphoid-specific gene and is rapidly induced in Th cells upon stimulation with anti-CD3. In in vitro assays, ROG represses the GATA-3-induced transactivation. Furthermore, overexpression of ROG in Th clones inhibits the production of Th cytokines. Taken together, our results suggest that ROG might play a critical role in regulating the differentiation and activation of Th cells. |
