| First Author | Huang L | Year | 1997 |
| Journal | Nat Genet | Volume | 17 |
| Issue | 3 | Pages | 292-7 |
| PubMed ID | 9354792 | Mgi Jnum | J:43841 |
| Mgi Id | MGI:1099009 | Doi | 10.1038/ng1197-292 |
| Citation | Huang L, et al. (1997) A novel gene involved in zinc transport is deficient in the lethal milk mouse. Nat Genet 17(3):292-7 |
| abstractText | We have identified the gene responsible for the inherited zinc deficiency in the lethal milk (lm) mouse. The gene, here designated Znt4, encodes a 430-amino-acid protein that is homologous to two proteins, ZnT2 and ZnT3, responsible for sequestration of zinc into endosomal/lysosomal compartments and synaptic vesicles, respectively. We show that the Znt4 gene confers zinc resistance to a zinc-sensitive yeast strain and that it is abundantly expressed in the mammary epithelia and brain. The lethal milk mutant: has a nonsense mutation at arginine codon 297 in the Znt4 gene. |
