| First Author | Gearing DP | Year | 1991 |
| Journal | EMBO J | Volume | 10 |
| Issue | 10 | Pages | 2839-48 |
| PubMed ID | 1915266 | Mgi Jnum | J:29552 |
| Mgi Id | MGI:77352 | Doi | 10.1002/j.1460-2075.1991.tb07833.x |
| Citation | Gearing DP, et al. (1991) Leukemia inhibitory factor receptor is structurally related to the IL-6 signal transducer, gp130. EMBO J 10(10):2839-48 |
| abstractText | Leukemia inhibitory factor (LIF) is a cytokine with a broad range of activities that in many cases parallel those of interleukin-6 (IL-6) although LIF and IL-6 appear to be structurally unrelated. A cDNA clone encoding the human LIF receptor was isolated by expression screening of a human placental cDNA library. The LIF receptor is related to the gp130 'signal-transducing' component of the IL-6 receptor and to the G-CSF receptor, with the transmembrane and cytoplasmic regions of the LIF receptor and gp130 being most closely related. This relationship suggests a common signal transduction pathway for the two receptors and may help to explain similar biological effects of the two ligands. Murine cDNAs encoding soluble LIF receptors were isolated by cross-hybridization and share 70% amino acid sequence identity to the human sequence. |
