| First Author | Wang CR | Year | 1991 |
| Journal | Cell | Volume | 66 |
| Issue | 2 | Pages | 335-45 |
| PubMed ID | 1855254 | Mgi Jnum | J:11339 |
| Mgi Id | MGI:59775 | Doi | 10.1016/0092-8674(91)90623-7 |
| Citation | Wang CR, et al. (1991) H-2M3 encodes the MHC class I molecule presenting the maternally transmitted antigen of the mouse. Cell 66(2):335-45 |
| abstractText | Mta, the maternally transmitted antigen of mice, is a hydrophobic, N-formylated mitochondrial peptide, MTF, presented on the cell surface to cytotoxic T lymphocytes by a novel major histocompatibility complex class I molecule, encoded by H-2M3. We have cloned and sequenced two alleles of M3, which differ in their ability to present MTF despite greater than 99% identity in the coding regions. M3 is as divergent from classical, antigen-presenting H-2 molecules as from other class I genes of the Hmt and the Qa/Tla regions. Amino acids critical for folding of class I molecules are conserved in M3. Noncharged amino acids lining the peptide-binding groove and phenylalanine 171 may explain the unique interaction with MTF, and leucine 95 appears critical for immunological activity. |
