| First Author | Do MS | Year | 1988 |
| Journal | Genomics | Volume | 3 |
| Issue | 3 | Pages | 195-200 |
| PubMed ID | 2906328 | Mgi Jnum | J:9628 |
| Mgi Id | MGI:58085 | Doi | 10.1016/0888-7543(88)90079-1 |
| Citation | Do MS, et al. (1988) Gene organization of murine homeobox-containing gene clusters. Genomics 3(3):195-200 |
| abstractText | A chromosomal walk which links a previously described and a new homeobox to the Hox-2 murine homeobox gene cluster is described, and the nucleotide sequence of the new homeobox is presented. With these new data the Hox-2 gene cluster contains seven loci on an approximately 100-kb-long physical map. Homology comparisons reveal that a significant number of vertebrate homeoboxes are in fact analogous. We also find that the linear order of homologous homeoboxes is similar in the two murine gene complexes, Hox-1 and Hox-2, and among the human homeobox loci on chromosome 17. Conservation of the homeo-domain and the linear gene order of homeobox-containing genes in vertebrates is discussed in light of the interactions and the anteroposterior linear order of homeotic loci in insects. |
