| First Author | Arden B | Year | 1985 |
| Journal | Nature | Volume | 316 |
| Issue | 6031 | Pages | 783-7 |
| PubMed ID | 3839904 | Mgi Jnum | J:7997 |
| Mgi Id | MGI:56466 | Doi | 10.1038/316783a0 |
| Citation | Arden B, et al. (1985) Diversity and structure of genes of the alpha family of mouse T-cell antigen receptor. Nature 316(6031):783-7 |
| abstractText | We have analysed 19 complementary DNA clones encoding the alpha-chain of the T-cell antigen receptor derived from thymic transcripts, and find that 15 of them contain partial or complete variable (V alpha) genes. Seven of these genes cross-hybridize to over 40 germline V alpha gene segments in Southern blot analyses. Of the 19 joining (J alpha) sequences examined, 18 seem to be encoded by distinct gene segments, hence the repertoire of J alpha gene segments is much larger than those of the immunoglobulin or T-cell receptor beta-chain gene families. We suggest that the variable domains of immunoglobulins and T-cell antigen receptors are similar in structure. |
