| First Author | Cathcart ES | Year | 1996 |
| Journal | Clin Immunol Immunopathol | Volume | 81 |
| Issue | 1 | Pages | 22-6 |
| PubMed ID | 8808637 | Mgi Jnum | J:35606 |
| Mgi Id | MGI:83054 | Doi | 10.1006/clin.1996.0152 |
| Citation | Cathcart ES, et al. (1996) Polymorphism of acute-phase serum amyloid A isoforms and amyloid resistance in wild-type Mus musculus czech. Clin Immunol Immunopathol 81(1):22-6 |
| abstractText | Until CE/J mice and their offspring were characterized as amyloid-resistant, all mice were thought to be amyloid-susceptible to multiple injections of azocasein or a single injection of silver nitrate following administration of amyloid enhancing factor. We now report, for the first time, that wild-type Mus musculus czech and F1 hybrids bred by crossing M. musculus czech with amyloid-susceptible CBA/J mice are also amyloid resistant. Based on the derived amino acid sequences of two serum amyloid A (SAA) cDNA clones, we describe two unusual SAA gene isoforms in M. musculus czech, one of which differs from four previously characterized acute-phase apoSAA isoforms at several amino acid residues. Our findings support the hypothesis that protection against amyloid fibril formation in wild-type M. musculus czech mice and their offspring is linked to apoSAA gene mutations (molecular motif). |
