| First Author | Parvanov ED | Year | 2010 |
| Journal | Science | Volume | 327 |
| Issue | 5967 | Pages | 835 |
| PubMed ID | 20044538 | Mgi Jnum | J:159887 |
| Mgi Id | MGI:4452589 | Doi | 10.1126/science.1181495 |
| Citation | Parvanov ED, et al. (2010) Prdm9 controls activation of mammalian recombination hotspots. Science 327(5967):835 |
| abstractText | Mammalian meiotic recombination, which preferentially occurs at specialized sites called hotspots, ensures the orderly segregation of meiotic chromosomes and creates genetic variation among offspring. A locus on mouse chromosome 17, which controls activation of recombination at multiple distant hotspots, has been mapped within a 181-kilobase interval, three of whose genes can be eliminated as candidates. The remaining gene, Prdm9, codes for a zinc finger containing histone H3K4 trimethylase that is expressed in early meiosis and whose deficiency results in sterility in both sexes. Mus musculus exhibits five alleles of Prdm9; human populations exhibit two predominant alleles and multiple minor alleles. The identification of Prdm9 as a protein regulating mammalian recombination hotspots initiates molecular studies of this important biological control system. |
