| First Author | Looman C | Year | 2003 |
| Journal | DNA Cell Biol | Volume | 22 |
| Issue | 8 | Pages | 489-96 |
| PubMed ID | 14565865 | Mgi Jnum | J:85621 |
| Mgi Id | MGI:2675872 | Doi | 10.1089/10445490360708892 |
| Citation | Looman C, et al. (2003) MZF6D, a novel KRAB zinc-finger gene expressed exclusively in meiotic male germ cells. DNA Cell Biol 22(8):489-96 |
| abstractText | Spermatogenesis takes place in the seminiferous tubule in the testes and culminates in the production of spermatozoa (male gametes). Here we report the identification of a novel mouse zinc-finger gene, MZF6D, which is selectively expressed in meiotic spermatocytes. The MZF6D protein contains an N-terminally located repressor domain, a KRAB domain, followed by at least seven successive Kruppel zinc-finger motifs. The KRAB domain of MZF6D, which consists of a KRAB A box and the newly identified KRAB C box, has previously been shown to interact with TIF1beta, which is the common corepressor of all KRAB zinc-finger proteins. Northern blot analysis shows that the expression of MZF6D is restricted to testes. This was confirmed by RT-PCR analysis of a panel of mouse tissues. In situ hybridization of sections from adult mouse testes localizes the expression to meiotic spermatocytes, suggesting a specific role for MZF6D in the regulation of spermatogenesis. |
