| First Author | Dib-Hajj SD | Year | 1995 |
| Journal | FEBS Lett | Volume | 377 |
| Issue | 3 | Pages | 485-8 |
| PubMed ID | 8549781 | Mgi Jnum | J:30352 |
| Mgi Id | MGI:77864 | Doi | 10.1016/0014-5793(95)01400-4 |
| Citation | Dib-Hajj SD, et al. (1995) Genes encoding the beta 1 subunit of voltage-dependent Na+ channel in rat, mouse and human contain conserved introns. FEBS Lett 377(3):485-8 |
| abstractText | We provide evidence in this study that the 86-bp insert in the beta 1.2 mRNA isoform of the voltage gated sodium channel is an intron. Transcripts still retaining this intron were detected in all tissues where the beta 1 gene expression was investigated. We also show that the exon/intron boundaries of the last two introns are conserved among rat, mouse and human beta 1 gene. Unlike the highly conserved cDNAs, introns in only the rat and mouse genes are highly related. The last intron is very short (86-90 bp) and is located in the 3' untranslated sequence, both uncommon properties of mammalian pre-mRNA introns. |
