| First Author | Schaniel C | Year | 1999 |
| Journal | Eur J Immunol | Volume | 29 |
| Issue | 9 | Pages | 2934-47 |
| PubMed ID | 10508268 | Mgi Jnum | J:57682 |
| Mgi Id | MGI:1345541 | Doi | 10.1002/(SICI)1521-4141(199909)29:09<2934::AID-IMMU2934>3.0.CO;2-Q |
| Citation | Schaniel C, et al. (1999) Three chemokines with potential functions in T lymphocyte-independent and -dependent B lymphocyte stimulation. Eur J Immunol 29(9):2934-47 |
| abstractText | Three clustered mouse chemokine genes, ABCD-1, -2 and -3, are all expressed highly in dendritic cells and, at various levels, in activated B cells. T cell-independently activated B cells express ABCD-1 and -2, but not -3. T cell-dependently activated B cells express all three. ABCD-1 attracts activated CD8+ cytotoxic T cells and CD4+ helper T cells of type 1 and 2. ABCD-2 preferentially attracts type 2 helper T cells, while ABCD-3 does not attract T cells at all. Both ABCD-1 and ABCD-2 bind to the same receptor (CCR4). In addition, ABCD-1 binds to a second, unknown, receptor on a separate T cell population. The three chemokines might guide T cell-independent as well as -dependent responses with two types of CD4+ T cells. |
