| First Author | Bruyns E | Year | 1996 |
| Journal | Genomics | Volume | 38 |
| Issue | 1 | Pages | 79-83 |
| PubMed ID | 8954783 | Mgi Jnum | J:36984 |
| Mgi Id | MGI:84390 | Doi | 10.1006/geno.1996.0595 |
| Citation | Bruyns E, et al. (1996) Sequence, genomic organization, and chromosomal localization of the human LPAP (PTPRCAP) and mouse CD45-AP/LSM-1 genes. Genomics 38(1):79-83 |
| abstractText | Human LPAP (lymphocyte phosphatase associated phosphoprotein) and its mouse homologue, CD45-AP (CD45 associated protein) or LSM-1, represent 32- and 30-kDa transmembrane phosphoproteins that noncovalently associate with the tyrosine phosphatase CD45, a key molecule involved in T- and B-lymphocyte activation. Here we report the isolation and sequencing of genomic clones of the human and mouse genes. LPAP (HGMW-approved symbol PTPRCAP) maps to human chromosome 11q13, distal to the BCL-1 breakpoint, and mouse CD4B-AP/LSM-1 maps to Chromosome 19B. Both genes span 3 kb and consist of two exons that are separated by a 1.2-kb intron. The promoter regions do not contain TATA boxes, but possess consensus transcriptional initiator sequences that have also been described for other TATA-less genes. The genomic sequences also provide a genetic basis for two different cDNAs (termed CD45-AP and LSIM-1, respectively) that have been described in the mouse system. (C) 1996 Academic Press, Inc. |
