| First Author | Nakamura N | Year | 2000 |
| Journal | J Biol Chem | Volume | 275 |
| Issue | 9 | Pages | 6523-9 |
| PubMed ID | 10692457 | Mgi Jnum | J:75403 |
| Mgi Id | MGI:2176429 | Doi | 10.1074/jbc.275.9.6523 |
| Citation | Nakamura N, et al. (2000) Syntaxin 7 mediates endocytic trafficking to late endosomes. J Biol Chem 275(9):6523-9 |
| abstractText | The lysosome functions are ensured by accurate membrane trafficking in the cell. We found that mouse syntaxin 7 could complement yeast vam3 and pep12 mutants defective in docking/fusion to vacuolar and prevacuolar membranes, respectively. Immunohistochemical studies showed that syntaxin 7 is localized to late endosomes, but not to early endosomes. Induced expression of mutant syntaxin 7 blocked endocytic transport from early to late endosomes but did not block the transport of cathepsin D and lamp-2 from the trans-Golgi network to lysosomes. Thus, syntaxin 7 mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes. These results also suggest that the biosynthetic pathway utilizes a different machinery from that of the endocytic pathway in the docking/fusion to late endosomes. |
