| First Author | Miaw SC | Year | 2004 |
| Journal | J Immunol | Volume | 172 |
| Issue | 1 | Pages | 170-7 |
| PubMed ID | 14688323 | Mgi Jnum | J:87094 |
| Mgi Id | MGI:2683373 | Doi | 10.4049/jimmunol.172.1.170 |
| Citation | Miaw SC, et al. (2004) A repressor of GATA-mediated negative feedback mechanism of T cell activation. J Immunol 172(1):170-7 |
| abstractText | The NF-AT family is a group of potent transcription factors that are essential for T cell activation in vitro. However, NF-ATc2-deficient Th cells display hyperproliferation in response to stimulation, suggesting that NF-ATc2 functions as a negative regulator of Th cell activation/proliferation. In this study we show that the transcriptional repressor of GATA (ROG) is a direct target gene of NF-ATc2 and that NF-ATc2-deficient Th cells are unable to fully up-regulate ROG upon stimulation. Restoration of ROG expression in vivo partly corrects the hyperproliferation of NF-ATc2-deficient Th cells by attenuating TCR signals. Our data, therefore, depict a ROG-mediated negative feedback mechanism of T cell activation. |
