| description | Protein which, if defective, causes diabetes insipidus, a rare form of diabetes in which the kidney tubules do not reabsorb enough water resulting in excessive urine excretion (polyuria). Two types of diabetes insipidus are recognized: central or neurohypophyseal diabetes insipidus which is due to defects in the neurohypophyseal system and results in a deficient quantity of anti-diuretic hormone being produced or released; nephrogenic diabetes insipidus, a vasopressin unresponsive condition of polyuria and hyposthenuria |