| description | Protein which, if defective, causes hereditary non-polyposis colorectal cancer (HNPCC), also known as Lynch's syndrome. It is an autosomal dominant syndrome which confers an increased risk for colorectal and endometrial cancers as well as others tumors Clinically, HNPCC is often divided into two subgroups: type I, characterized by a hereditary predisposition to colorectal cancer, a young age of onset, and carcinoma observed in the proximal colon; type II, characterized by an increased risk for cancers in certain tissues such as the uterus, ovary, breast, stomach, small intestine, skin, and larynx in addition to the colon |
Ontology Term --> All ancestors
Ontology Term --> All descendants
Ontology Term --> Direct children
Ontology Term --> Direct parents
